IL16 variants associated with prostate cancer risk in African Americans

Batai, K., et al. (2012). “Fine-Mapping of IL16 Gene and Prostate Cancer Risk in African Americans.” Cancer Epidemiology Biomarkers & Prevention 21(11): 2059-2068.

My first paper, “Fine-mapping of IL16 gene and prostate cancer risk in African Americans,” was published on the November  issue of Cancer Epidemiology, Biomarkers, and Prevention last year (here).

You may think why my paper is related to anthropological genetics, but there are at least three reasons that I can think of why anthropologists should conduct more research projects related to genetic epidemiology and cancer genetics.

1) Cancer health disparities – many types of cancer are more common among African Americans, due to their gene, biology, or socio-cultural factors.  Anthropologists are uniquely trained to understand the relationship of these factors.

2) I used IMPUTE to estimate untyped genotype using 1000 Genomes data as references.  Imputation method used is based on population genetics and require understanding population history.  I also used STRUCTURE to estimate individual’s genetic ancestry, which was used to correct for effect of population stratification.

3) Evolutionary geneticists may think that cancer risk is not affected by evolutionary process, because people get cancer after reproductive age, but we have to look at the processes or mechanisms of cancer development.  Inflammatory response is important in cancer development and inflammation is common or more severe among African populations.

I believe there are a lot more that anthropologists can learn from other disciplines.



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